3-Deazaneplanocin A hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

一种高效且具有竞争性的 S-腺苷高半胱氨酸水解酶抑制剂，Ki 为 0.05 nM。

A highly potent and competitive S-adenosylhomocysteine hydrolase inhibitor with Ki of 0.05 nM, also inhibits histone methyltransferase EZH2; more potent than 3-deazaaristeromycin; induces EZH2 protein depletion, leads to cell death in several cancers and tumors; anticancer or antiviral agent.

3-Deazaneplanocin A (20-200 nM, during 16-28 day) stimulates Oct4 expression in chemically induced pluripotent stem cells (CiPSCs).3-Deazaneplanocin A (20-200 nM, during 16-28 day) inhibits DNA and H3K9 methylation at the Oct4 promoter in CiPSCs.3-Deazaneplanocin A (10 nM, 24 h) promotes developmental competence of cloned pig embryos.3-Deazaneplanocin A (10 nM, 24 h) decreases the levels of H3K27me3 and H3K9me2 at the 2-cell, 4-cell and blastocyst stages. Immunofluorescence Cell Line:Cloned pig embryos Concentration:10?nM Incubation Time:24 h Result:Decreased H3K27me3 and H3K9me2 by approximately 45%, 37% and 7% at the 2-cell, 4-cell and blastocyst stages, respectively.

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DZNep hydrochloride | NSC 617989 hydrochloride | 3-Deazaneplanocin hydrochloride

Chromatin/Epigenetic

HMTase

HMTase

Cancer

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120964-45-6

298.7255

C12H15ClN4O3

>98% (HPLC)

10 mM in DMSO

O[C@@H]1[C@H](O)C(CO)=C[C@H]1N2C=NC3=C2C=CN=C3N.[H]Cl

3-Cyclopentene-1,2-diol, 5-(4-amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-, hydrochloride (1:1), (1S,2R,5R)-

(-20℃)

With Ice Pack

≥ 2 years